Intellectual Property
An extensive intellectual property portfolio protects Aperion product candidates and Z-Process® technology. Currently, 28 U.S. and international patents have been issued and a number are pending. Aperion’s patent portfolio includes claims relating to treatment and application of specific tissues for a variety of medical and surgical uses. The intellectual property portfolio includes combined patents of process and material composition that support deantigenation, sterilization and viral inactivation of a wide range of biological tissues. Aperion has exclusive rights to the only known method for humanizing non-primate animal grafts for replacement of ligaments, bone, etc. in humans without making the graft inert.
Patents regarding Z-Process® include coverage of key immunochemical modification and sterilization techniques as applied to a variety of animal-derived tissues, including connective tissue grafts (tendon, ligament, articular cartilage and fibrocartilage); cardiovascular tissues (heart valve and pericardium); and calcified and de-calcified bone (granular bone matrix, cortical and cancellous structural bone for struts, cages and machined implants). The patent portfolio also includes immunochemical modifications of solubilized and homogenized dermal- and tendon-derived injectable collagen formulations.
Aperion Biologics (formerly CrossCart) Issued Patents
Patent Number Title
- 5782915 ARTICULAR CARTILAGE HETEROGRAFTS
- 5865849 MENISCAL HETEROGRAFTS
- 5902338 ANTERIOR CRUCIATE LIGAMENT HETEROGRAFT
- 5913900 SUBSTANTIALLY NATIVE MENISCAL CARTILAGE HETEROGRAFTS
- 5922027 ARTICULAR CARTILAGE HETEROGRAFTS
- 5944755 ARTICULAR CARTILAGE XENOGRAFTS
- 5984858 MENISCAL XENOGRAFTS
- 6046379 MENISCAL XENOGRAFTS
- 6049025 ARTICULAR CARTILAGE XENOGRAFTS
- 6063120 ANTERIOR CRUCIATE LIGAMENT HETEROGRAFT
- 6093204 MENISCAL HETEROGRAFTS
- 6110206 ANTERIOR CRUCIATE LIGAMENT XENOGRAFTS
- 6210440 ANTERIOR CRUCIATE LIGAMENT XENOGRAFTS
- 6231608 ALDEHYDE AND GLYCOSIDASE-TREATED SOFT AND BONE TISSUE XENOGRAFTS
- 6267786 PROTEOGLYCAN-REDUCED SOFT TISSUE XENOGRAFTS
- 6383732 XENOGRAFT HEART VALVES
- 6402783 ANTERIOR CRUCIATE LIGAMENT XENOGRAFTS
- 6455309 PROTEOGLYCAN-REDUCED SOFT TISSUE XENOGRAFTS
- 6758865 SOFT TISSUE XENOGRAFTS
- 6972041 BONE XENOGRAFTS
- 7064187 SUBSTANTIALLY NON-IMMUNOGENIC INJECTIBLE COLLAGEN
- 7594934B2 GALACTOSIDASE-TREATED PROSTHETIC DEVICES
- 7595377B2 SUBSTANTIALLY NON-IMMUNOGENIC INJECTABLE COLLAGEN
- 7645568B2 XENOGRAFT HEART VALVES
- 7722622B2 BONE XENOGRAFTS
- EPO1065997 BONE XENOGRAFTS
- EPO1511445 STERILIZED XENOGRAFT TISSUE
PUBLICATIONS
"Anterior Cruciate Ligament Reconstruction with a Porcine Xenograft A Serologic, Histologic, and Biomechanical Study in Primates."Stone KR, Walgenbach AW, Turek TJ, Somers DL, Wicomb W, Galili U. Arthroscopy: The Journal of Arthroscopic and Related Surgery. April2007;23:411-419.
"Replacement of Human Anterior Cruciate Ligaments with Pig Ligaments: A Model for Anti-Non-Gal Antibody Response in Long-Term Xenotransplantation." Stone KR, Abdel-Motal UM, Walgenbach AW, Turek TJ, Galili U. Transplantation. January 2007;83:211-219.
"Porcine Cartilage Transplants in Cynomolgus Monkey: III. Transplantation of Alpha Galactosidase Treated Porcine Cartilage." Stone KR, Ayala G, Goldstein J, Hurst R, Walgenbach AW, Galili U. Transplantation, Vol. 65, No. 12, pg. 1577-1583, June 27, 1998.
"Porcine and Bovine Cartilage Transplants in Cynomolgus Monkey: II. Changes in Anti-Gal Response During Chronic Rejection."Galili U, LaTemple DC, Walgenbach AW, Stone KR. Transplantation, Vol. 63, No. 5, pg. 646-651, March 15, 1997.
"Porcine and Bovine Cartilage Transplants In Cynomolgus Monkey: I. A Model for Chronic Xenograft Rejection.. Stone KR, Walgenbach AW, Abrams JT, Nelson J, Gillett N, Galili U. Transplantation, Vol. 63, No. 5, pg. 640-645, March 15, 1997.
PRESENTATIONS
"Cartilage and Xenografts." Stone KR, Turek, TJ. 8th World Congress of the International Cartilage Repair Society, Miami FL, May 24, 2009.
"Treatment of ACL Ruptures with Xenografts. Where Are We Today?" Stone KR, Walgenbach AW, Turek TJ. Congress of the Portuguese Association of Arthroscopy and Sports Traumatology, Oeiras, Portugal, September 27, 2007.
"Immunological Considerations in Orthopaedic Xenografting." Stone KR, Walgenbach AW, Turek TJ, Galili U. ISAKOS 6th Biennial Congress, Florence Italy, May 27, 2007.
"Xenograft Ligament Transplantation: Development of a Porcine Xenograft for ACL Reconstruction." Stone KR, Turek TJ. XXIV Congreso de la Asociacion Espanola de Artroscopia, Leon, Spain, May 12, 2006.
"ACL Reconstruction with a Porcine Xenograft." Stone KR, Walgenbach AW, Turek TJ, Galili U. ACL Study Group Meeting, Kona, Hawaii, March 28, 2006.
"Xenograft Ligament Transplantation." Stone KR, Walgenbach AW, Turek TJ, Galili U. American Association of Tissue Banks Spring Meeting, Tucson, Arizona, March 26, 2006.
"A Six-Month Biomechanical and Histological Evaluation of Porcine Xenografts for Anterior Cruciate Ligament Reconstruction." Stone KR , Turek TJ, , Somers D, Wicomb W, Galili U. International Orthopaedic Research Society Meeting, Banff Canada, February 2005
"A Six-Month Biomechanical and Histological Evaluation of Porcine Xenografts for Anterior Cruciate Ligament Reconstruction." Stone KR , Turek TJ, Hansen T, Gealer R, Walgenbach AW, Somers D, Wicomb W, Galili U. American Orthopaedic Society for Sports Medicine, San Diego, California, July 22, 2003.
"A Six-Month Biomechanical and Histological Evaluation of Porcine Xenografts for Anterior Cruciate Ligament Reconstruction." Stone KR, ACL Study Group Meeting, Big Sky, Montana, March 4, 2002.
"Xenograft ACL Device Development." Stone KR, Walgenbach AW, Turek TJ, Wicomb W, Galili U. Australian Knee Society Annual Scientific Meeting, Hobart, Australia, October 8 - 13, 2000.
"Xenograft Ligament Reconstruction." Stone KR, Walgenbach AW. ACL Study Group, Rhodes, Greece, May 20 - 26, 2000.
POSTER SESSIONS
“Mechanism of Rejection in Orthopaedic Xenografts". Turek TJ, Stone KR, Walgenbach Aw, Lee DR, Galili U, Society for Biomaterials, San Antonio TX, April 23, 2009
"Long-Term follow-up of Anterior Criciate Ligament Reconstruction Using an Immunochemically Modified Porcine Patellat Tendon ." Stone KR, Turek TJ, Walgenbach AW, Smith S, Galili U. International Symposium on Tendon and Ligaments – VIII, Las Vegas, Nevada, February 22, 2009.
"Porcine Xenografts as Functional Scaffolds for ACL Reconstruction." Stone KR, Walgenbach AW, Turek TJ, Galili U. International Symposium on Tendon and Ligaments – VI, Chicago, Illinois, March 18, 2006.
"Immunological Considerations in Orthopaedic Xenografting." Stone KR, Walgenbach AW, Turek TJ. Orthopaedic Research Society, Chicago, Illinois, March 2006.
"Porcine Patellar Tendon Grafts for Anterior Cruciate Ligament Reconstruction." Stone KR, Walgenbach AW, Turek TJ, Somers D, Wicomb W, Galili U. The International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, Montreaux, Switzerland, May 2001.
"Xenograft Implantation of Porcine Patellar Tendon: A Histological, Serological, and Bio-Mechanical Study." Stone KR, Walgenbach AW, Turek TJ, Hansen T, Galili. U Orthopaedic Research Society, February 2001.
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